Flash ads, noisy ads, blinky ads and popup ads are terrible. I will block them like the plague.
As was pointed out on slashdot:
"...figure out another way to make money. If you business model is based upon annoying the shit out everybody, ripping through cycles, and just peddling bullshit on your website, then just have the guts to fail instead of begging people to play along with your stupid business plan."
I have used AdBlock before but do not always run it. I find that NoScript http://www.blogger.com/img/blank.gifmakes browsing much more bearable on older machines while retaining perfect control over which scripts to run. Highly recommended.